TTFields harness physics to disrupt mitosis in cancer cells1-3
In preclinical models, TTFields have been shown to disrupt mitosis in cancer cells by exerting electric forces on their polar components (eg, microtubule spindle formation during mitosis), disrupting their normal localization (place in cell membrane) and function, ultimately leading to cell death.1-3
Watch below to see how TTFields disrupt mitosis in cancer cells
References: 1. Karanam NK, Srinivasan K, Ding L, Sishc B, Saha D, Story MD. Tumor-treating fields elicit a conditional vulnerability to ionizing radiation via the downregulation of BRCA1 signaling and reduced DNA double-strand break repair capacity in non-small cell lung cancer cell lines. Cell Death Dis. 2017;8(3):1-10. doi:10.1038/cddis.2017.136 2. Karanam NK, Ding L, Aroumougame A, Story MD. Tumor treating fields cause replication stress and interfere with DNA replication fork maintenance: implications for cancer therapy. Transl Res. 2020;217:33-46. doi:10.1016/j.trsl.2019.10.003 3. Shteingauz A, Porat Y, Voloshin T, et al. AMPK-dependent autophagy upregulation serves as a survival mechanism in response to Tumor Treating Fields (TTFields). Cell Death Dis. 2018;9:1074. doi:10.1038/s41419-018-1085-9